Role of adipocyte-derived extracellular vesicles in vascular inflammation

Extracellular vesicles (EVs) are nanometre-sized released from most cells, including adipocytes. Relatively little is known about adipocyte-derived EVs (ADEVs) in comparison to other EV subtypes, though interest ADEVs as potential paracrine and endocrine communicators of adipose tissue obesity building. Current evidence indicates that contribute the development dysfunction; a key feature obese it associated with obesity-related comorbidities cardiovascular disease (CVD). This review summarises our current knowledge dysfunction disrupt redox signalling exert vascular effects may exacerbate CVD obesity. • contain diverse cargo specific proteins, lipids RNAs can affect cell function locally distally. Adipocyte alters content ADEVs. patients induce inflammation. initiate endothelial facilitate complications. Both adipocytes cause oxidative stress though, role biology has not yet been explored.